Scientific Papers

S. mutans

1. He, J., M.H. Anderson, W. Shi, and R. Eckert. Design and activity of a "dual-targeted" antimicrobial peptide. International Journal of Antimicrobial Agents. 2009. In Press: doi:10.1016/j.ijantimicag.2008.11.013.



2. He J, Eckert R, Pharm T, Simanian MD, Hu C, Yarbrough DK, Qi F, Anderson MH, Shi W. Novel synthetic antimicrobial peptides against Streptococcus mutans. Antimicrob Agents Chemother. 2007 Apr;51(4):1351-8. Epub 2007 Feb 12



3. Eckert R, He J, Yarbrough DK, Qi F, Anderson MH, Shi W. Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide. Antimicrob Agents Chemother. 2006 Nov;50(11):3651-7.

P. aeruginosa

4. Eckert R, Mchardy I, Yarbrough DK, He J, Qi F, Anderson MH, Shi W. Stability and activity in sputum of G10KHc, a potent anti-Pseudomonas antimicrobial peptide. Chem Biol Drug Des. 2007 Nov;70(5):456-60. Epub 2007 Oct 10.



5. Eckert R, Brady KM, Greenberg EP, Qi F, Yarbrough DK, He J, McHardy I, Anderson MH, Shi W. Enhancement of antimicrobial activity against pseudomonas aeruginosa by coadministration of G10KHc and tobramycin. Antimicrob Agents Chemother. 2006 Nov;50(11):3833-8.



6. Eckert R, Qi F, Yarbrough DK, He J, Anderson MH, Shi W. Adding selectivity to antimicrobial peptides: rational design of a multidomain peptide against Pseudomonas spp. Antimicrob Agents Chemother. 2006 Apr;50(4):1480-8.

Botanicals: Herbal Lollipop

7. He J, Chen L, Shi W, Lu, Q-Y. Antibacterial compounds from Glycyrrhiza uralensis. Journal of Natural Products. 2006 Jan;69(1):121-4.



8. Belt, D. Licorice root lollipop shows sweet promise in reducing tooth decay. Journal of the California Dental Association. 2008 Apr;36(4):243,249.



9. How Many Licks Does it Take to Reduce Tooth Decay? Delta Dental press release on two clinical studies with the herbal lollipop. 2008 Sep. [Update Sept 09: Clinical study results are positive and a publication has been accepted by the Journal of Functional Foods. Manuscript will be posted after publication]

Media Coverage

• 2008-Dec-29. Researchers Aim to 'STAMP' Out Harmful Bacteria. Science Today at the University of California.
• 2007-Jun-11. Biofilms—slimy layers of bacteria that antibiotics don't fully kill-are in hospitals, kitchens, even your mouth. Scientists are on the attack. Los Angeles Times.
• 2007-Jan-01. 'Smart' Antimicrobial Treatment Developed. American Dental Association. J Am Dent Assoc, Vol 138, No 1, 33-34.
• 2006-Dec-01. Targeted Antimicrobial Peptides Could Help Stamp Out Tooth Decay. Microbe, Volume 1, Number 12, 2006
• 2006-Oct-23. Researchers Report Initial Success in Promising Approach to Prevent Tooth Decay. National Institute of Dental and Craniofacial Research Science News Release.
• 2006-Oct-26. UCLA School of Dentistry Creates New Weapon in Fight Against Tooth Decay. UCLA Press Release.
• 2006-Apr-21. First "Smart" Antimicrobial Reported. National Institute of Dental and Craniofacial Research Science News in Brief.
• 2006-Apr-18. UCLA School of Dentistry Researchers Prepare to STAMP out Pathogens with Smart Bomb Antimicrobial Technology. UCLA Press Release.