Publications

Anti-Streptococcus Mutans Therapeutic Development

View» Yarbrough DK, Eckert R, He J, Hagerman E, Qi F, Lux R, Wu B, Anderson MH, Shi W. Rapid probing of biological surfaces with a sparse-matrix peptide library. PLoS ONE, 2011 August;6(8): e23551.
View» Sullivan R, Santarpia P, Lavender S, Gittins E, Liu Z, Anderson MH, He J, Shi W, Eckert R. Clinical efficacy of a specifically targeted antimicrobial peptide mouth rinse: Targeted elimination of Streptococcus mutans and prevention of demineralization. Caries Research 2011;45(5):415-428
View» Kaplan CW, Sim JH, Shah KR, Kolesnikova-Kaplan A, Shi W, Eckert R. Selective membrane disruption: Mode of action of C16G2, a specifically targeted antimicrobial peptide. Antimicrob Agents Chemother, 2011 Jul; 55:3446-3452.
View» He J, Yarbrough DK, Kreth J, Anderson MH, Shi W, Eckert, R. A systematic approach to optimizing specifically-targeted antimicrobial peptides against Streptococcus mutans. Antimicrob Agents Chemother, 2010 May;54(5):2143-51. Epub 2010 Mar 8.
View» Li L, Guo LH, Lux R, Eckert R, Yarbrough DK, He J, Anderson M, Shi W. Targeted antimicrobial therapy against Streptococcus mutans establishes protective non-cariogenic oral biofilms and reduces subsequent infection. International Journal of Oral Science, 2010 April;1(2):66-73
View» Li L, He J, Eckert R, Yarbrough D, Lux R, Anderson M, Shi W. Design and characterization of an acid-activated antimicrobial peptide. Chemical Biology & Drug Design, 2010 Jan;75(1):127-32
View» He J, Anderson M, Shi W, Eckert R. Design and activity of a 'dual-targeted' antimicrobial peptide. International Journal of Antimicrobial Agents, 2009 Jun;33(6):532-7
View» He J, Eckert R, Pharm T, Simanian MD, Hu C, Yarbrough DK, Qi F, Anderson MH, Shi W. Novel synthetic antimicrobial peptides against Streptococcus mutans. Antimicrob Agents Chemother, 2007 Apr;51(4):1351-8. Epub 2007 Feb 12
View» Eckert R, He J, Yarbrough DK, Qi F, Anderson MH, Shi W. Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide. Antimicrob Agents Chemother, 2006 Nov;50(11):3651-7.

Biomineralization Peptides

View» Yarbrough DK, Hagerman E, Eckert R, He J, Choi H, Cao N, Le K, Hedger J, Qi F, Anderson M, Rutherford B, Wu B, Tetradis S, Shi W. Specific binding and mineralization of calcified surfaces by small peptides. Calcified Tissue International, 2010 Jan;86(1):58-66